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Chemical Structure : CSRM617
CAS No.: 787504-88-5
Catalog No.: PC-35864Not For Human Use, Lab Use Only.
CSRM617 (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CSRM617 (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly,
CSRM617 inhibits cell growth and induced apoptosis in vitro in several PC cell lines that expressed moderate to high levels of OC2,
CSRM617 significantly downregulates PEG10 protein levels in tumors from mice treated with CSRM617, suppresseses metastasis in 22Rv1 cells implanted subcutaneously nude mice.
| M.Wt | 255.23 | |
| Formula | C10H13N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzylidene)propanehydrazide |
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1. Rotinen M, et al. Nat Med. 2018 Nov 26. doi: 10.1038/s41591-018-0241-1.
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