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AB680

Chemical Structure : AB680

CAS No.: 2105904-82-1

AB680 (AB-680, Quemliclustat)

Catalog No.: PC-35840Not For Human Use, Lab Use Only.

AB680 (Quemliclustat) is a highly potent, selective, reversible inhibitor of CD73 with Ki/IC50 of 4.9/70 pM (hCD73).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AB680 (Quemliclustat) is a highly potent, selective, reversible inhibitor of CD73 with Ki/IC50 of 4.9/70 pM (hCD73).
AB680 displays > 10,000-fold selectivity against related ecto-nucleotidases (CD39, NTPDases 2/3/8) and a large panel of unrelated enzymes, receptors, and ion channels.
AB680 completely inhibits CD73 enzymatic activity on CD8+ T cell, robustly restores proliferation of human CD4+ T-cells and reverses AMPmediated inhibition of IFN-γ and IL-2 production, limits the inhibitory effect of AMP on CD4+ T cell proliferation with IC50 of 4.5 nM.
AB680 also potently restored CD25 expression on human CD8+ T cells.

Physicochemical Properties

M.Wt 580.83
Formula C20H24ClFN4O9P2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 200 mg/mL

Chemical Name/SMILES

(((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid

References

1. Piovesan D, et al. Mol Cancer Ther. 2022 Apr 11:molcanther.0802.2021.
2. Lawson KV, et al. J Med Chem. 2020 Oct 22;63(20):11448-11468.

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