Cat. No. |
Product Name |
Information |
PC-35333 |
EC-359
LIFR inhibitor
|
EC-359 (EC359) is a first-in-class, orally available inhibitor of leukemia inhibitory factor (LIF), blocks LIF-LIFR interaction and binds to LIFR with affinity of 81 nM in SPR assay. |
PC-35330 |
CCG-222740
MRTF/SRF inhibitor
|
CCG-222740 (CCG222740) is a pharmacological inhibitor of MRTF/SRF signalling, shows greater inhibitory effect on MRTF/SRF target genes than MRTF-A inhibitor CCG-203971, with IC50 of 5 uM in fibroblast-mediated collagen contraction assay. |
PC-35313 |
S-C025
OXE-R inhibitor
|
S-C025 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor, OXE-R) with IC50 of 0.12 nM. |
PC-35242 |
Z-590
MIF inhibitor
|
Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity. |
PC-35241 |
ISO-92
MIF inhibitor
|
ISO-92 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity with IC50 of 0.55 uM. |
PC-35233 |
SAN9812
|
SAN9812 (Carnostatine) is a potent, highly selective, competitive inhibitor of Carnosinase 1 (CN1) activity with Ki of 11 nM. |
PC-35219 |
AZD5904
MPO inhibitor
|
AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat. |
PC-35212 |
4-CPPC
MIF-2 inhibitor
|
4-CPPC is the first reversible and selective inhibitor of pro-inflammatory protein macrophage migration inhibitory factor-2 (MIF-2) with Ki of 33 uM, 13-fold selectivity for human MIF-2 versus human MIF-1. |
PC-35205 |
IACS-010759
OXPHOS inhibitor
|
IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain. |
PC-35175 |
VTI-1002
|
VTI-1002 is a first-in-class, highly potent, selective inhibitor of human Granzyme B (GzmB) with Ki of 4.4 nM, exhibits strong selectivity for GzmB over caspases 3-10, cathepsin G, and neutrophil elastase. |
PC-35134 |
AA147
ATF6 agonist
|
AA147 is a specific, small molecule agonist of transcription factor ATF6, activates ATF6 and influences differentiation of stem cells. |
PC-35108 |
BTZO-2
MIF activator
|
BTZO-2 is an active BTZO-1 derivative, an antioxidant response element-activator, provides protection against lethal endotoxic shock in mice.. |