Catalog No.: PC-73159Not For Human Use, Lab Use Only.
JHU37160 is a high affinity, highly potent, BBB penetrant activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro.
JHU37160 is a high affinity, highly potent, BBB penetrant activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro.
JHU37152 selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites.
JHU37152 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons.
Designer receptors exclusively activated by designer drugs (DREADD) technology is a powerful chemogenetic approach used for neuromodulation in uninstrumented research animals.
