| Cat. No. |
Product Name |
Information |
| PC-72130 |
WO-459
GPR52 agonist
|
WO-459 (WO459) is the first potent and orally available agonist of GPR52 with pEC50 of 7.53. |
| PC-72129 |
GPR52 antagonist E7
GPR52 antagonist
|
GPR52 antagonist E7 is a novel Gpr52 antagonist, shows significant inhibitory effect on WO-459 (100 nM)-induced cAMP elevation in HEK293/GPR52 cells with IC50 of 12.0 uM. |
| PC-72128 |
CAY10786
GPR52 antagonist
|
CAY10786 (GPR52 antagonist Comp-43) is a highly potent and specific GPR52 antagonist with IC50 of 0.63 uM. |
| PC-72127 |
PW0787
GPR52 agonist
|
PW0787 (PW 0787) is a potent, selective, brain-penetrant GPR52 agonist with EC50 of 135 nM in cAMP assays in HEK293 cells. |
| PC-72124 |
AGF347
SHMT2 inhibitor
|
AGF347 (AGF-347) is a small molecule inhibitor targeting mitochondrial C1 metabolism at SHMT2 (in vitro Ki=2.19 uM), also directly targers the purine biosynthetic enzymes GARFTase (Ki=3.13 uM) and AICARFTase (Ki=3.72 uM), and SHMT1 (Ki=2.91 uM). |
| PC-72110 |
MK-8719
O-GlcNAcase inhibitor
|
MK-8719 (MK8719) is a a highly potent, selective, CNS-penetrable inhibitor of O-GlcNAcase (OGA) with Ki of 7.9 nM (hOGA). |
| PC-72103 |
AM9053
NAAA inhibitor
|
AM9053 (AM 9053) is a potent, selective inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 30 nM, with limited effect on FAAH activity (IC50>100 uM). |
| PC-72102 |
ARN19689
NAAA inhibitor
|
ARN19702 (ARN-19702) is potent, selective, non-covalent inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 42 nM (h-NAAA). |
| PC-72101 |
ARN19702
NAAA inhibitor
|
ARN19702 (ARN-19702) is potent, selective, orally active, reversible inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 230 nM. |
| PC-72080 |
GMFBI.1
GMF-β inhibitor
|
GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM. |
| PC-72079 |
INH-12
HSD17B12 inhibitor
|
INH-12 is a selective small-molecule HSD17B12 inhibitor with 70% inhibition of HSD17B12 activity to transform estrone (E1) into estradiol (E2) at 1 uM, reduces the replication of Flaviviridae viruses (HCV, DENV and ZIKV). |
| PC-72078 |
NCGC00507974
Mir155 inhibitor
|
NCGC00507974 is a small molecule inhibitor of Mir155 reporter, dose-dependently inhibits Mir155 reporter expression with EC50 of 1.2 uM. |
