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Chemical Structure : MLS000544460
Catalog No.: PC-72461Not For Human Use, Lab Use Only.
MLS000544460 (EYA2i) is a specific, allosteric inhibitor of Eya2 phosphatase with IC50 of 4.1 uM, KD of 2.0 uM, does not bind Eya3 ED, Eya1 and Eya4 ED.
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MLS000544460 (EYA2i) is a specific, allosteric inhibitor of Eya2 phosphatase with IC50 of 4.1 uM, KD of 2.0 uM, does not bind Eya3 ED, Eya1 and Eya4 ED.
MLS000544460 inhibits Eya2-mediated cell migration.
MLS000544460 decreased mesenchymal phenotypes and enhanced cancer cell immunogenicity, resulting in attenuated tumor growth and metastasis.
MLS000544460 treatment increased infiltration of cytotoxic T and NK cells, and enhanced anti-PD-1 therapy response in mouse tumor models.
Inhibition of the EYA2 Tyr phosphatase activity via MLS000544460, mimicked EYA2 loss in glioblastoma stem cells (GSCs) in vitro and extended the survival of tumor-bearing mice.
| M.Wt | 341.36 | |
| Formula | C17H12FN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang G, et al. J Exp Med. 2021 Nov 1;218(11):e20202669.
2. Jia Z Shen, et al. Mol Cell. 2022 Feb 11;S1097-2765(22)00087-9.
3. Krueger AB, et al. J Biol Chem. 2014 Jun 6;289(23):16349-61.
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