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NCGC00378430

Chemical Structure : NCGC00378430

CAS No.: 920650-00-6

NCGC00378430 (Compound 8430)

Catalog No.: PC-72451Not For Human Use, Lab Use Only.

NCGC00378430 (Compound 8430) is a novel small molecule compound that reduces the SIX1/EYA2 interaction in vitro with IC50 of 52 uM in the Alphascreen assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NCGC00378430 (Compound 8430) is a novel small molecule compound that reduces the SIX1/EYA2 interaction in vitro with IC50 of 52 uM in the Alphascreen assay.
NCGC00378430 partially reversed transcriptional and metabolic profiles mediated by SIX1 overexpression and reversed SIX1-induced TGF-β signaling and epithelial-mesenchymal transition (EMT), also reverses SIX1-induced TGF-β signaling and EMT in vitro in breast cancer cells.
NCGC00378430 had little toxicity in vivo.
NCGC00378430 disrupts the SIX1-EYA2 interaction and transcriptional activity, partially reverses SIX1-mediated transcriptional and metabolic signatures in breast tumor cells.
NCGC00378430 inhibits TGF-β signaling and EMT in breast cancer cells with high SIX1 expression.
NCGC00378430 inhibits metastasis of breast cancer cells expressing high levels of SIX1 in vivo.

Physicochemical Properties

M.Wt 441.502
Formula C22H23N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-Methoxy-3-(morpholinosulfonyl)phenyl)-3-(1H-pyrrol-1-yl)benzamide

References

1. Hengbo Zhou, et al. Cancer Res. 2020 Jun 15;80(12):2689-2702.

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