| Cat. No. |
Product Name |
Information |
| PC-21457 |
K161
SHIP1/2 inhibitor
|
K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively. |
| PC-21366 |
ATUX-1215
PP2A activator
|
ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo. |
| PC-20969 |
Compound 182
PTP1B/PTPN2 inhibitor
|
Compound 182 is a highly potent and selective active site competitive inhibitor of PTP1B and PTPN2, inhibits the catalytic activities of PTP1B and PTPN2 with IC50 of 0.63 and 0.58 nM, respectively. |
| PC-20711 |
SBI-221
SHP2-E76K inhibitor
|
SBI-221 is a small molecule inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM and 7.4 uM for SHP2-E76K and SHP2-WT in isothermal CETSA assays, respectively. |
| PC-20470 |
PTP1B inhibitor BDB
PTP1B inhibitor
|
PTP1B inhibitor BDB is a natural compound found in marine red algaea, is a selective, cell‐permeable and competitive inhibitor of PTP1B with IC50 of 1.86 uM. |
| PC-20469 |
PTP1B inhibitor BBR
PTP1B inhibitor
|
PTP1B inhibitor BBR is a selective, non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B with IC50 of 8 uM. |
| PC-20365 |
HN252
PPM1B inhibitor
|
HN252 is a potent protein phosphatase 1B (PPM1B) inhibitor with Ki of 0.52 uM and IC50 of 0.76 uM, shows no inhibition against topoisomerases in vitro. |
| PC-20341 |
PHPS1 sodium
SHP2 inhibitor
|
PHPS1 sodium is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM. |
| PC-20340 |
PHPS1
SHP2 inhibitor
|
PHPS1 is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM. |
| PC-20339 |
PTPN2 inhibitor 9
PTPN2 inhibitor
|
PTPN2 inhibitor 9 (PTP9) is small molecule inhibitor of protein tyrosine phosphatase non-receptor type 2 (PTPN2), sensitizes tumor cells to IFNγ treatment in vitro and to anti-PD-1 therapy in vivo. |
| PC-20250 |
JAB-3068
SHP2 inhibitor
|
JAB-3068 (JAB3068) is a potent, selective and orally bioavailable allosteric inhibitor of SHP2 with IC50 of 25.8 nM. |
| PC-20047 |
GDC-1971
SHP2 inhibitor
|
Migoprotafib (GDC-1971, RLY-1971) is a potent, selective, allosteric and orally bioavailable inhibitor of the non-receptor protein tyrosine phosphatase SHP2 (PTPN11), potently inhibits both wild-type SHP2 (IC50 <1 nM) and E76K activating mutant (IC50 < 250nM) in biochemical assays. |
