| Cat. No. |
Product Name |
Information |
| PC-73317 |
ABBV-CLS-484
Dual PTPN2/N1 inhibitor
|
ABBV-CLS-484 (AC484, Osunprotafib) is a first-in-class, orally bioavailable, potent and selective PTPN2 and PTPN1 active-site inhibitor with IC50 of 1.8 and 2.5 nM, respectively. |
| PC-73092 |
NRT-870-59
PTP4A3 inhibitor
|
NRT-870-59 is a potent, reversible PTP4A3 inhibitor (IC50=86 nM) with inhibitory specificity for PTP4A3 versus both PTP4A3 A111S mutant and CDC25B. |
| PC-73091 |
JMS-053
PTP4A inhibitor
|
JMS-053 (KVX-053) is a potent, selective, reversible, and noncompetitive PTP4A inhibitor with IC50 of 50/53/18 nM for PTP4A1/PTP4A2/PTP4A3, respectively. |
| PC-73052 |
DJ001
PTPσ inhibitor
|
DJ001 (DJ-001, UCLA 5483071) is a highly selective, allosteric protein tyrosine phosphatase-sigma (PTPσ) inhibitor with IC50 of 1.5 uM. |
| PC-72996 |
NSC45586 free base
PHLPP2 inhibitor
|
NSC45586 free base (NCS 45586, NCI45586) is a potent, specific PHLPP2 inhibitor with IC50 of 4 uM, targets the PHLPP2 PP2C domain, suppresses MYC and triggers cell death. |
| PC-72973 |
DIPQUO
Alkaline phosphatase activator
|
DIPQUO is a small molecule activator of the bone marker alkaline phosphatase (ALP) expression with EC50 of 6.27 uM, p38-β mediate DIQPUO-driven osteoblast differentiation effect. |
| PC-72803 |
MPK5 inhibitor 1
MKP5 inhibitor
|
MPK5 inhibitor 1 (MPK5-IN-1, MPK5 inhibitor compound 1) is a potent, selective allosteric inhibitor of MAPK phosphatase MKP5 with Kd/IC50 of 1.0/3.9 uM. |
| PC-72611 |
PF-07284892
SHP2 inhibitor
|
PF-07284892 (ARRY-558) is a potent, selective allosteric SHP2 inhibitor with IC50 of 21 nM, has 1,000-fold selectivity for SHP2 over 21 other phosphatases, including the closely related SHP1. |
| PC-72527 |
SMIP-30
PPM1A inhibitor
|
SMIP-30 is a potent and selective inhibitor of PPM1A with IC50 of 1 uM, selectively inhibits the phosphatase activity of PPM1A. |
| PC-72526 |
SCP1 inhibitor T-62
SCP1 inhibitor
|
SCP1 inhibitor T-62 (T-62) is a specific, small molecule covalent inhibitor of small CTD phosphatase 1 (SCP1), reduces transcription factor REST protein level HEK293 cells. |
| PC-72524 |
SCP1 inhibitor T-65
SCP1 inhibitor
|
SCP1 inhibitor T-65 (T-65) is a specific, small molecule covalent inhibitor of small CTD phosphatase 1 (SCP1), reduces transcription factor REST protein level HEK293 cells with EC50 of 1.5 uM. |
| PC-72326 |
TK-453
SHP2 inhibitor
|
TK-453 (TK453) is a potent, selective SHP2 allosteric inhibitor with IC50 of 18.76 and 179 nM for SHP2-WT and SHP2-E76K, respectively. |
