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Lockdown Ester Prodrug

Chemical Structure : Lockdown Ester Prodrug

CAS No.: 2985814-80-8

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Lockdown Ester Prodrug (Lockdown Pro)

Catalog No.: PC-38405Not For Human Use, Lab Use Only.

Lockdown Ester Prodrug (Lockdown Pro) is the ester-modified Lockdown with increased membrane permeability and prodrug-like properties, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Lockdown Ester Prodrug (Lockdown Pro) is the ester-modified Lockdown with increased membrane permeability and prodrug-like properties, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion.
    Lockdown Ester Prodrug (Lockdown Pro) effectively block PPM1F-mediated effects on integrin β1 and PAK in cells, Lockdown Pro suppresses tissue invasion by PPM1F-overexpressing human cancer cells.

    Physicochemical Properties

    M.Wt 668.739
    Formula C39H40O10
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    tetraethyl 4,4'-((propane-2,2-diylbis(4,1-phenylene))bis(oxy))diphthalate

    References

    1. Grimm TM, et al. Cell Chem Biol. 2022 Apr 15:S2451-9456(22)00128-3.

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