| Cat. No. |
Product Name |
Information |
| PC-62319 |
Guanabenz
PP1-PPP1R15A inhibitor
|
Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-PPP1R15A holophosphatase complex. |
| PC-61822 |
SHP244
SHP2 inhibitor
|
SHP244 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 60 uM (SHP2 1-525), equipotent on the double mutant (SHP2T253M/Q257L IC50=68 uM), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM). |
| PC-61676 |
AKB-9778
VE-PTP inhibitor
|
AKB-9778 (Razuprotafib) is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP, HPTPβ) with IC50 of 17 pM. |
| PC-61276 |
II-B08
SHP2 inhibitor
|
II-B08 is a potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs. |
| PC-61275 |
SHP2 inhibitor 11a-1
SHP2 inhibitor
|
SHP2 inhibitor 11a-1 is a potent, selective, cell-active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs. |
| PC-61273 |
SHP2 inhibitor 2
SHP2 inhibitor
|
SHP2 inhibitor 2 is a nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM. |
| PC-61272 |
GS-493
SHP2 inhibitor
|
GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay. |
| PC-61271 |
Fumosorinone
SHP2 inhibitor
|
Fumosorinone is a novel potent, selective protein tyrosine phosphatase SHP2 inhibitor with IC50 of 6.31 uM. |
| PC-61176 |
NSC 87877
SHP1/2 inhibitor
|
NSC 87877 is potent, selective protein tyrosine phosphatase SHP1 and SHP2 with IC50 of 318 and 355 nM, respectively, also inhibits dual-specificity phosphatase 26 (DUSP26). |
| PC-61175 |
RR601
DUSP5 inhibitor
|
RR601 is a potent, selective protein tyrosine phosphatase DUSP5, PTP1B and SHP-2 inhibitor with IC50 of 36 uM, 2.1 uM and 1.1 uM respectively, 8-fold selectivity for PTP1B versus DUSP5. |
| PC-60897 |
ML400
LMPTP inhibitor
|
ML400 is a potent, selective, allosteric LMPTP inhibitor with IC50 of 1.68 uM, displays good selective against other phosphatases. |
| PC-60896 |
LMPTP inhibitor 23
LMPTP inhibitor
|
LMPTP inhibitor 23 is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM. |
