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NSC117079

Chemical Structure : NSC117079

CAS No.: 500363-63-3

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NSC117079 (NSC-117079;NSC 117079)

Catalog No.: PC-60664Not For Human Use, Lab Use Only.

NSC117079 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NSC117079 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
    NSC117079 also inhibits PHLPP2, has no activities against other phosphatases.
    NSC117079 activated AKT and ameliorates staurosporine-induced cell death in neurons.

    Physicochemical Properties

    M.Wt 473.474
    Formula C20H15N3O7S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-amino-9,10-dioxo-4-((3-sulfamoylphenyl)amino)-9,10-dihydroanthracene-2-sulfonic acid

    References

    1. Jackson TC, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.

    2. Sierecki E, et al. J Med Chem. 2010 Oct 14;53(19):6899-911.

    3. Hwang SM, et al. J Orthop Res. 2017 Oct 25. doi: 10.1002/jor.23781.

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