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Chemical Structure : NSC117079
Catalog No.: PC-60664Not For Human Use, Lab Use Only.
NSC117079 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
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NSC117079 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
NSC117079 also inhibits PHLPP2, has no activities against other phosphatases.
NSC117079 activated AKT and ameliorates staurosporine-induced cell death in neurons.
| M.Wt | 473.474 | |
| Formula | C20H15N3O7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jackson TC, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.
2. Sierecki E, et al. J Med Chem. 2010 Oct 14;53(19):6899-911.
3. Hwang SM, et al. J Orthop Res. 2017 Oct 25. doi: 10.1002/jor.23781.
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