| Cat. No. |
Product Name |
Information |
| PC-49039 |
PP2Cδ (WIP1) inhibitor C23
PP2Cδ inhibitor
|
PP2Cδ inhibitor C23 is a potent PP2Cδ (WIP1, PPM1D) inhibitor, not only directly inhibits PP2Cδ activity but also suppresses high glucose (HG)-induced PP2Cδ expression. |
| PC-49037 |
CCT007093
PP2Cδ/PPM1D/Wip1 inhibitor
|
CCT007093 is a small-molecule inhibitor of PP2Cδ (WIP1, PPM1D) with IC50 of 8.4 uM, selectively reduces viability of human tumour cell lines. |
| PC-38898 |
K306
SHIP1 agonist
|
K306 is a specific, small molecule agonist of SH2-containing 5' inositol phosphatase 1 (SHIP1) with EC50 of 119 nM, 10-fold higher selectivity over SHIP2. |
| PC-38538 |
AQX-016A
SHIP1 agonist
|
AQX-016A is a potent, selective small molecule agonist of SHIP1 phosphatase activity, upregulates SHIP1 activity in the PI3K signaling pathway in cells, without acitivty for SHIP2 phosphatase activity. |
| PC-38476 |
GSK2830371
PPM1D inhibitor
|
GSK2830371 (GSK 2830371) is a potent, selective orally active, allosteric inhibitor of Wip1 phosphatase (PPM1D) with IC50 of 6 nM, inhibits endogenous substrates phospho-p38 MAPK (T180) with IC50 of 13 nM. |
| PC-38405 |
Lockdown Ester Prodrug
PPM1F inhibitor
|
Lockdown Ester Prodrug (Lockdown Pro) is the ester-modified Lockdown with increased membrane permeability and prodrug-like properties, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion. |
| PC-38404 |
Lockdown
PPM1F inhibitor
|
Lockdown is a selective, reversible and non-competitive inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion. |
| PC-73348 |
NHB1109
PTPRD inhibitor
|
NHB1109 (Pentilludin) is a potent, selective, orally active PTPRD phosphatase inhibitor with IC50 of 0.6 uM, displays selectivity over PTPRS, PTPRF, PTPRJ or PTPN1/PTP1B phosphatases. |
| PC-73317 |
ABBV-CLS-484
Dual PTPN2/N1 inhibitor
|
ABBV-CLS-484 (AC484, Osunprotafib) is a first-in-class, orally bioavailable, potent and selective PTPN2 and PTPN1 active-site inhibitor with IC50 of 1.8 and 2.5 nM, respectively. |
| PC-73092 |
NRT-870-59
PTP4A3 inhibitor
|
NRT-870-59 is a potent, reversible PTP4A3 inhibitor (IC50=86 nM) with inhibitory specificity for PTP4A3 versus both PTP4A3 A111S mutant and CDC25B. |
| PC-73091 |
JMS-053
PTP4A inhibitor
|
JMS-053 (KVX-053) is a potent, selective, reversible, and noncompetitive PTP4A (phosphatase of regenerating liver, PRL) inhibitor with IC50 of 50/53/18 nM for PTP4A1/PTP4A2/PTP4A3, respectively. |
| PC-73052 |
DJ001
PTPσ inhibitor
|
DJ001 (DJ-001, UCLA 5483071) is a highly selective, allosteric protein tyrosine phosphatase-sigma (PTPσ) inhibitor with IC50 of 1.5 uM. |
