| Cat. No. |
Product Name |
Information |
| PC-72034 |
PTPN22 inhibitor L-1
PTPN22 inhibitor
|
PTPN22 inhibitor L-1 is a selective, competitive small molecule inhibitor of PTPN22 with IC50 of 1.4 uM, Ki of 0.5 uM, 7- to 10-fold selectivity for PTPN22 over 16 similar PTPs. |
| PC-72033 |
CNBDA
SHP2 inhibitor
|
CNBDA is a novel selective Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitor with IC50 of 5 uM, 25-fold selectivity over SHP1. |
| PC-38186 |
IACS-15414
SHP2 inhibitor
|
IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM. |
| PC-38184 |
SBI-4668
SHP2 inhibitor
|
SBI-4668 (SBI-668) is a novel furanylbenzamide molecule inhibitor of both WT and oncogenic SHP2 with IC50 of 0.73/1.8 uM for Wt SHP2/SHP2-E76K, 13-fold selective over PTP1B and 73-fold selective over STEP. |
| PC-38183 |
SBI-2130
SHP2 inhibitor
|
SBI-2130 (SBI 2130) is a novel furanylbenzamide molecule inhibitor of both WT and oncogenic SHP2 with IC50 of 0.22/5.0 uM for Wt SHP2/SHP2-E76K. |
| PC-38181 |
RMC-4630
SHP2 inhibitor
|
RMC-4630 (Vociprotafib) is a potent and selective inhibitor of SHP2, a central node in the RAS signaling pathway. |
| PC-38180 |
TNO155
SHP2 inhibitor
|
Batoprotafib (TNO155) is a highly potent, selective, orally active, and allosteric SHP2 (PTPN11) inhibitor with IC50 of 11 nM. |
| PC-38070 |
IACS-13909
SHP2 inhibitor
|
IACS-13909 (IACS13909) is a potent, and selective allosteric inhibitor of SHP2 with IC50 of 15.7 nM (hSHP2 full length), Kd of 32 nM (ITC). |
| PC-36051 |
SHP2 inhibitor 14
|
SHP2 inhibitor 14 is a novel potent, selective, allosteric, orally acitve SHP2 inhibitor with IC50 of 28 nM. |
| PC-36050 |
SHP389
SHP2 inhibitor
|
SHP389 (SHP-389, SHP 389) is a novel potent, selective, allosteric SHP2 inhibitor with IC50 of 36 nM, shows with impressive hERG selectivity (IC50>30 uM). |
| PC-36040 |
SHP2 inhibitor 9
SHP2 inhibitor
|
SHP2 inhibitor 9 is a potent, selective inhibitor of SHP2 with IC50 of 48 nM, inhibits p-ERK in KYSE520 cells with IC50 of 28 nM. |
| PC-36039 |
SHP2 inhibitor 8
SHP2 inhibitor
|
SHP2 inhibitor 8 is a potent, selective inhibitor of SHP2 with IC50 of 5 nM, inhibits p-ERK in KYSE520 cells with IC50 of 5 nM. |
