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CNBDA

Chemical Structure : CNBDA

CAS No.: 2101321-90-6

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CNBDA (SHP2 inhibitor CNBDA)

Catalog No.: PC-72033Not For Human Use, Lab Use Only.

CNBDA is a novel selective Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitor with IC50 of 5 uM, 25-fold selectivity over SHP1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CNBDA is a novel selective Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitor with IC50 of 5 uM, 25-fold selectivity over SHP1.
    Treatment HER2-positive BC cells with CNBDA suppressed cell proliferation in 2D culture, anchorage-independent growth in soft agar, and mammosphere (tumorisphere) formation in suspension cultures in a concentration-dependent manner.
    CNBDA inhibited EGF-induced signaling and expression of HER2 by inhibiting the PTPase activity of SHP2 in BC cells.

    Physicochemical Properties

    M.Wt 512.643
    Formula C30H40O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4,4'-(4'-carboxy-4-(nonyloxy)-[1,1'-biphenyl]-3,5-diyl)dibutyric acid

    References

    1. Zachary Hartman, et al. ACS Omega. 2020 Sep 25;5(39):25113-25124.

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