| Cat. No. |
Product Name |
Information |
| PC-22856 |
Thienopyridone
PRL/PTP4A inhibitor
|
Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatases inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1 (PTP4A1), PRL-2 (PTP4A2), and PRL-3 (PTP4A3), respectively. |
| PC-22839 |
Cyclosporin A
PP2B inhibitor
|
Cyclosporin A (CsA, Cyclosporine A) is a immunosuppressant agent and highly specific inhibitor of the Ca2+/calmodulin-dependent protein phosphatase PP2B with IC50 of 65 nM in rat pancreatic acinar cells. |
| PC-22546 |
SMIP-031
PPM1A inhibitor
|
SMIP-031 is a potent small molecule inhibitor of metal-dependent phosphatase PPM1A with IC50 of 180 nM, efficiently activates autophagy and reduces the mycobacterium tuberculosis (Mtb) infection. |
| PC-22375 |
CDC14 phosphatase inhibitor 15
CDC14 inhibitor
|
CDC14 phosphatase inhibitor 15 is a first-in-class, potent, selective, and bioavailable inhibitor of CDC14 phosphatase with IC50 of 93 nM and 220 nM for human CDC14A and CDC14B, respectively, >50-fold selective over other PTPs. |
| PC-22168 |
SCP1 inhibitor GR-28
SCP1/REST inhibitor
|
SCP1 inhibitor GR-28 is a covalent small molecule inhibitor of small C-terminal domain phosphatase 1 (SCP1) with kinact/KI 1383 min-1 M-1, causes degrades REST protein in REST-dependent glioblastoma cells. |
| PC-21910 |
G6P3510
CLas STP inhibitor
|
G6P3510 is a specific Candidatus Liberibacter spp dual-specificity phosphatase (CLas STP) with binding KD of 81.4 uM, confers plant tolerance to Candidatus Liberibacter spp. |
| PC-21504 |
PRL inhibitor Cmpd-43
PRL inhibitor
|
PRL inhibitor Cmpd-43 is a specific small molecule inhibitor and detrimerizer of phosphatase of regenerating liver (PRL), significantly decreases PRL1 trimer formation inside the cell. |
| PC-21456 |
NGD61181
SHIP2 inhibitor
|
NGD61181 is a pyrazole-based SHIP2 inhibitor, has micromolar binding affinity and inhibitory activity, does not contain a phosphatase “warhead,” binds the active site of SHIP2. |
| PC-21455 |
SHIP1 inhibitor 23
SHIP1 inhibitor
|
SHIP1 inhibitor 23 is a small molecule SHIP1 inhibitor with IC50 of 6.5 uM in in the ratio pAKT/tAKT determined by Alpha SureFire assays. |
| PC-21454 |
AS1938909
SHIP2 inhibitor
|
AS1938909 is a potent, selective and competitive SHIP2 inhibitor with Ki value of 0.44 uM (human SHIP2), shows significant selectivity over other related phosphatases. |
| PC-21359 |
ATUX-792
PP2A activator
|
ATUX-792 is a small molecule activator of protein phosphatase 2A (PP2A), decreases survival, proliferation, and motility of neuroblastoma in vitro and tumor growth in vivo. |
| PC-21296 |
PP5 inhibitor P053
PP5 inhibitor
|
PP5 inhibitor P053 (Compound P053) is a potent, selective and competitive inhibitor of serine/threonine protein phosphatase-5 (PP5) with Ki of 244 nM, specifically binds and inhibits PP5 activity. |
