SHIP1 inhibitor 23

Chemical Structure : SHIP1 inhibitor 23

Catalog No.: PC-21455Not For Human Use, Lab Use Only.

SHIP1 inhibitor 23 is a small molecule SHIP1 inhibitor with IC50 of 6.5 uM in in the ratio pAKT/tAKT determined by Alpha SureFire assays.

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Biological Activity

SHIP1 inhibitor 23 is a small molecule SHIP1 inhibitor with IC50 of 6.5 uM in in the ratio pAKT/tAKT determined by Alpha SureFire assays.
SHIP1 inhibitor 23 induces phagocytosis of both BV2 and HMC3 cells with IC50 of 540 nM, does not result in significant changes in either cell count or nuclear intensity.
SHIP1 inhibitor 23 also activates primary mouse microglia isolated from neonate mice.

Physicochemical Properties

M.Wt	403.31
Formula	C20H20Cl2N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2,4-dichlorobenzyl)oxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl) pyridine

References

1. Cynthia D Jesudason, et al. Alzheimers Dement (N Y). 2023 Nov 17;9(4):e12429.

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