Chemical Structure : CDC14 phosphatase inhibitor 15
CAS No.:
CDC14 phosphatase inhibitor 15
Catalog No.: PC-22375Not For Human Use, Lab Use Only.
CDC14 phosphatase inhibitor 15 is a first-in-class, potent, selective, and bioavailable inhibitor of CDC14 phosphatase with IC50 of 93 nM and 220 nM for human CDC14A and CDC14B, respectively, >50-fold selective over other PTPs.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDC14 phosphatase inhibitor 15 is a first-in-class, potent, selective, and bioavailable inhibitor of CDC14 phosphatase with IC50 of 93 nM and 220 nM for human CDC14A and CDC14B, respectively, >50-fold selective over other PTPs.
CDC14 phosphatase inhibitor 15 dose-dependently increased both p53 Ser315 phosphorylation and p53 protein levels in U2OS cells
CDC14 phosphatase inhibitor 15 showed no considerable cytotoxic effects across all tested cells at 50 uM.
CDC14 phosphatase inhibitor 15 showed a good PK profile with acceptable exposure and elimination to enable its use as a chemical probe for future in vivo studies.
Physicochemical Properties
|
M.Wt
|
400.32
|
|
Formula
|
C21H15F2O4P
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(difluoro(4-(1-phenylvinyl)dibenzo[b,d]furan-1-yl)methyl)phosphonic acid
|
References
1. Dong J, et al. J Med Chem. 2024 May 20. doi: 10.1021/acs.jmedchem.4c00149.
Contact Us
sales@probechem.com
