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PP5 inhibitor P053

Chemical Structure : PP5 inhibitor P053

CAS No.: 1022417-69-1

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PP5 inhibitor P053 (Compound P053)

Catalog No.: PC-21296Not For Human Use, Lab Use Only.

PP5 inhibitor P053 (Compound P053) is a potent, selective and competitive inhibitor of serine/threonine protein phosphatase-5 (PP5) with Ki of 244 nM, specifically binds and inhibits PP5 activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PP5 inhibitor P053 (Compound P053) is a potent, selective and competitive inhibitor of serine/threonine protein phosphatase-5 (PP5) with Ki of 244 nM, specifically binds and inhibits PP5 activity.
PP5 inhibitor P053 does not bind to PP2A.
PP5 inhibitor P053 significantly inhibits cell proliferation in VHL-null ccRCC cells, 786-O and A498 compared to normal epithelial renal cell HK2 as well as VHL-positive ccRCC cell lines Caki-1 and Caki-2.
PP5 inhibitor P053 induces extrinsic apoptosis in clear cell renal cell carcinoma.

Physicochemical Properties

M.Wt 342.41
Formula C18H18N2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-benzylphenyl)-3,5-dimethylisoxazole-4-sulfonamide

References

1. Ahanin EF, et al. Cell Chem Biol. 2023 Oct 19;30(10):1223-1234.e12.

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