Cyclosporin A | PP2B inhibitor | Probechem Biochemicals

Chemical Structure : Cyclosporin A

CAS No.: 59865-13-3

Cyclosporin A (Cyclosporine A, CsA)

Catalog No.: PC-22839Not For Human Use, Lab Use Only.

Packing	Price	Stock
100 mg	$48	In stock
500 mg	$98	In stock
1 g	$148	In stock
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Biological Activity

Cyclosporin A (CsA, Cyclosporine A) is a immunosuppressant agent and highly specific inhibitor of the Ca2+/calmodulin-dependent protein phosphatase PP2B with IC50 of 65 nM in rat pancreatic acinar cells.
Cyclosporin A also inhibits cholecystokinin-, 100 pM, or carbamylcholine-, 10 microM, induced amylase release in a concentration-dependent manner.
Cyclosporin A specifically blocks the cholecystokinin-stimulated dephosphorylation of a 24-kDa protein in a concentration range similar to that seen for inhibition of secretion.
Cyclosporin A stimulates glucose-induced insulin secretion by inhibiting the activity of PP2B, an event that may be involved in mechanisms governing glucose-induced insulin secretion via dephosphorylation of synapsin I-like protein in MIN6 cells.

Physicochemical Properties

M.Wt	1202.64
Formula	C62H111N11O12
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

References

1. Groblewski GE, et al. J Biol Chem. 1994 May 27;269(21):15111-7.

2. Yoshida T, et al. J Cell Sci. 1994 Jul;107 ( Pt 7):1725-35.

3. Ebihara K, et al. Endocrinology. 1996 Dec;137(12):5255-63.

Cyclosporin A (Cyclosporine A, CsA)

Biological Activity

Physicochemical Properties

References

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