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Chemical Structure : Cyclosporin A
CAS No.: 59865-13-3
Catalog No.: PC-22839Not For Human Use, Lab Use Only.
Cyclosporin A (CsA, Cyclosporine A) is a immunosuppressant agent and highly specific inhibitor of the Ca2+/calmodulin-dependent protein phosphatase PP2B with IC50 of 65 nM in rat pancreatic acinar cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $48 | In stock | |
| 500 mg | $98 | In stock | |
| 1 g | $148 | In stock | |
| 5 g | Get quote |
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Cyclosporin A (CsA, Cyclosporine A) is a immunosuppressant agent and highly specific inhibitor of the Ca2+/calmodulin-dependent protein phosphatase PP2B with IC50 of 65 nM in rat pancreatic acinar cells.
Cyclosporin A also inhibits cholecystokinin-, 100 pM, or carbamylcholine-, 10 microM, induced amylase release in a concentration-dependent manner.
Cyclosporin A specifically blocks the cholecystokinin-stimulated dephosphorylation of a 24-kDa protein in a concentration range similar to that seen for inhibition of secretion.
Cyclosporin A stimulates glucose-induced insulin secretion by inhibiting the activity of PP2B, an event that may be involved in mechanisms governing glucose-induced insulin secretion via dephosphorylation of synapsin I-like protein in MIN6 cells.
| M.Wt | 1202.64 | |
| Formula | C62H111N11O12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone |
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1. Groblewski GE, et al. J Biol Chem. 1994 May 27;269(21):15111-7.
2. Yoshida T, et al. J Cell Sci. 1994 Jul;107 ( Pt 7):1725-35.
3. Ebihara K, et al. Endocrinology. 1996 Dec;137(12):5255-63.
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