| Cat. No. |
Product Name |
Information |
| PC-25611 |
PRLthiophenib
PRL-3 inhibitor
|
PRLthiophenib is a potent, selective inhibitor of phosphatase of regenerating liver 3 (PRL-3, PRL3) with IC50 of 7.8 uM, shows mucher weaker inhibitor for PRL-1 and -2 (IC50=31 uM and 15.8 uM), binds directly to PRL-3 with Kd of 23 uM. |
| PC-25608 |
Licoflavone A
PTP1B inhibitor
|
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B) with IC50 of 54.5 uM, also has anti-gastric cancer potency in vitro and in vivo, affects the proliferation, cycle, apoptosis, migration, invasion, and EMT by targeting VEGFR-2 and blocks the PI3K/AKT and MEK/ERK signaling pathways. |
| PC-24886 |
Z218484536
PSPH inhibitor
|
Z218484536 is a potent and specific phosphoserine phosphatase (PSPH) inhibitor, inhibits the release of L-serine from cultured astrocytes with IC50 of 0.4 uM, reduces cellular L-serine levels with IC50 of 0.38 uM. |
| PC-24875 |
JUN-1111
Cdc25 inhibitor
|
JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. |
| PC-24364 |
Laforin inhibitor 9c
Laforin inhibitor
|
Laforin inhibitor 9c is a highly potent, selective inhibitor of glycogen phosphatase laforin with IC50 of 4.0 nM and Ki value of 1.9 nM, >8000-fold selective over other 15 PTPs. |
| PC-23908 |
PTPN22 inhibitor IC-11
PTPN22 inhibitor
|
I-C11 is a selective, reversible inhibitor of protein tyrosine phosphatase non-receptor type 22 (PTPN22, LYP) with IC50 of 4.6 uM. |
| PC-23638 |
PTPN22 inhibitor 8b
PTPN22 inhibitor
|
PTPN22 inhibitor 8b is a potent, selective inhibitor of lymphoid-specific tyrosine phosphatase (LYP, PTPN22) with Ki/IC50 of 110/260 nM, > 9-fold selectivity over a large panel of PTPs. |
| PC-23637 |
PTPN22 inhibitor 8b-19
PTPN22 inhibitor
|
PTPN22 inhibitor 8b-19 is a potent, selective inhibitor of protein tyrosine phosphatase non-receptor type 22 (PTPN22) with IC50 of 0.25 uM, 15.2-fold and 19.2-fold selectivity against SHP2 and PTP1B, respectively. |
| PC-23571 |
Ethoxysanguinarine
CIP2A inhibitor
|
Ethoxysanguinarine (ESG) is an effective small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and its downstream signaling molecules, c-Myc and pAkt, and induces protein phosphatase 2A (PP2A) activity. |
| PC-23570 |
CIP2A inhibitor TD52
CIP2A inhibitor
|
TD52 is a small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and p-Akt, reactivates protein phosphatase 2A. |
| PC-23264 |
SP3-12
SHIP-1 inhibitor
|
SP3-12 is a novel selective small molecule inhibitor of Src Homology 2-containing Inositol 5'-Phosphatase-1 (SHIP-1, encoded by INPP5D) with IC50 of 6.1 uM and Ki of 3.2 µM, 7-fold selectivity over SHIP-2. |
| PC-23195 |
SPI-112
SHP2 inhibitor
|
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50 of 1 uM. |
