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Chemical Structure : ENT-03
Catalog No.: PC-23188Not For Human Use, Lab Use Only.
ENT-03 is a centrally acting spermine bile acid, potently inhibits PTP1B with IC50 of 10 nM, induces weight loss in obese and lean rodents.
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ENT-03 is a centrally acting spermine bile acid, potently inhibits PTP1B with IC50 of 10 nM, induces weight loss in obese and lean rodents.
ENT-03 reduces food intake and body weight in the mouse and rat, with the anticipated metabolic consequences.
ENT-03 reduces hepatic steatosis ENT-03 inhibits PTP1b and induces phosphorylation of STAT3 in the hypothalamus and choroid plexus.
ENT-03 upregulates cFos activation in brain regions involved in satiety and appetite regulation.
| M.Wt | 618.99 | |
| Formula | C37H70N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Denise Barbut, et al. Diabetes Obes Metab. 2024 Sep 22. doi: 10.1111/dom.15940.
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