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You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-ENT-03
ENT-03

Chemical Structure : ENT-03

CAS No.: 2962076-06-6

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ENT-03 (ENT03)

Catalog No.: PC-23188Not For Human Use, Lab Use Only.

ENT-03 is a centrally acting spermine bile acid, potently inhibits PTP1B with IC50 of 10 nM, induces weight loss in obese and lean rodents.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ENT-03 is a centrally acting spermine bile acid, potently inhibits PTP1B with IC50 of 10 nM, induces weight loss in obese and lean rodents.
ENT-03 reduces food intake and body weight in the mouse and rat, with the anticipated metabolic consequences.
ENT-03 reduces hepatic steatosis ENT-03 inhibits PTP1b and induces phosphorylation of STAT3 in the hypothalamus and choroid plexus.
ENT-03 upregulates cFos activation in brain regions involved in satiety and appetite regulation.

Physicochemical Properties

M.Wt 618.99
Formula C37H70N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

Cholestan-26-oic acid, 3-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-7-hydroxy-, (3β,5α,7α,25S)-

References

1. Denise Barbut, et al. Diabetes Obes Metab. 2024 Sep 22. doi: 10.1111/dom.15940.

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