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SP3-12

Chemical Structure : SP3-12

CAS No.:

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SP3-12 (SP 3-12)

Catalog No.: PC-23264Not For Human Use, Lab Use Only.

SP3-12 is a novel selective small molecule inhibitor of Src Homology 2-containing Inositol 5'-Phosphatase-1 (SHIP-1, encoded by INPP5D) with IC50 of 6.1 uM and Ki of 3.2 µM, 7-fold selectivity over SHIP-2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SP3-12 is a novel selective small molecule inhibitor of Src Homology 2-containing Inositol 5'-Phosphatase-1 (SHIP-1, encoded by INPP5D) with IC50 of 6.1 uM and Ki of 3.2 µM, 7-fold selectivity over SHIP-2.
SP3-12 significantly improved phagocytosis, achieving an EC50 of 2.0 µM in the pHrodo-myelin assay using human microglial clone 3 (HMC3) cells.
SP3-12 represents a novel class of small molecule SHIP-1 inhibitors, demonstrating both selectivity and cellular activity.

Physicochemical Properties

M.Wt 442.52
Formula C29H22N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

8-([1,1′-biphenyl]-4-yl)-5-amino-9-oxo-9,10,11,12-tetrahydro-8H-quinolino[1,2-a]quinazoline-7-carbonitrile

References

1. Miao J, et al. Bioorg Med Chem. 2024 Oct 19;114:117965.

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