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Chemical Structure : SP3-12
Catalog No.: PC-23264Not For Human Use, Lab Use Only.
SP3-12 is a novel selective small molecule inhibitor of Src Homology 2-containing Inositol 5'-Phosphatase-1 (SHIP-1, encoded by INPP5D) with IC50 of 6.1 uM and Ki of 3.2 µM, 7-fold selectivity over SHIP-2.
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SP3-12 is a novel selective small molecule inhibitor of Src Homology 2-containing Inositol 5'-Phosphatase-1 (SHIP-1, encoded by INPP5D) with IC50 of 6.1 uM and Ki of 3.2 µM, 7-fold selectivity over SHIP-2.
SP3-12 significantly improved phagocytosis, achieving an EC50 of 2.0 µM in the pHrodo-myelin assay using human microglial clone 3 (HMC3) cells.
SP3-12 represents a novel class of small molecule SHIP-1 inhibitors, demonstrating both selectivity and cellular activity.
| M.Wt | 442.52 | |
| Formula | C29H22N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Miao J, et al. Bioorg Med Chem. 2024 Oct 19;114:117965.
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