| Cat. No. |
Product Name |
Information |
| PC-35159 |
Benzarone
EYA PTP inhibitor
|
Benzarone (NSC 82134) is a small molecule inhibitor of Eyes Absen (EYA) protein tyrosine phosphatase activity (IC50=17 uM, EYA3), exhibits selectivity for EYA over PTP1B. |
| PC-35138 |
MLS-0437605
DUSP3 inhibitor
|
MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.). |
| PC-35116 |
RMC-4550
SHP2 inhibitor
|
RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM. |
| PC-35024 |
MY33-3
PTPRZ1 inhibitor
|
MY33-3 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation. |
| PC-35023 |
MY10
RPTPβ/ζ inhibitor
|
MY10 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation. |
| PC-63257 |
SHP2-IN-2
SHP2 inhibitor
|
SHP2-IN-2 is a selective, allosteric inhibitor of protein tyrosine phosphatase SHP2, preferentially inhibits SHP2 F285S over the PTP domain and allosteric site mutant. |
| PC-42970 |
TCS401
PTP1B inhibitor
|
TCS-401 (TCS401) is a potent, selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with Ki of 0.29 uM, weakly inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 with Ki of 59, 560, 1,100, >2,000, >2,000, and >2,000 uM. |
| PC-42809 |
Alendronate sodium hydrate
PTPepsilon inhibitor
|
Alendronate sodium hydrate (Alendronate, MK 217, G-704650 Adronat) is a bisphosphonate that acts as a specific inhibitor of osteoclastmediated bone resorption, inhibits osteoclast protein-tyrosine phosphatase (PTPepsilon) with IC50 of 2 uM. |
| PC-62844 |
PTP1B-IN-5b
PTP1B inhibitor
|
PTP1B-IN-5b is a potent protein tyrosine phosphatase PTP1B inhibitor with IC50 of 5.25 uM. |
| PC-62801 |
TC-2153
STEP inhibitor
|
TC-2153 (TC2153) is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM. |
| PC-62749 |
DBK-1154
PP2A activator
|
SMAP-2 (DT-1154, DBK1154) is an orally bioavailable small molecule activator of PP2A, binds to PP2A Aα scaffold subunit and inhibits KRAS-driven tumor growth both in vitro and in vivo. |
| PC-62748 |
RTC-30
PP2A activator
|
RTC-30 is an orally active, dual pathway inhibitor of PI3K-AKT and RAS-ERK signaling via putative activation of the tumor suppressor PP2A, exhibits GI50 of 15 uM against H1650 lung adenocarcinoma cells. |
