Catalog No.: PC-35504Not For Human Use, Lab Use Only.
Guanabenz acetate (Wytensin, WY-8678 acetate) is a small molecule that binds to PPP1R15A/GADD34, selectively disrupts the stress-induced dephosphorylation of eIF2α.
Guanabenz acetate (Wytensin, WY-8678 acetate) is a small molecule that binds to PPP1R15A/GADD34, selectively disrupts the stress-induced dephosphorylation of eIF2α.
Guanabenz acetate prolongs eIF2α phosphorylation in human stressed cells, without affecting the related PPP1R15B-phosphatase complex and constitutive protein synthesis.
Guanabenz acetate accelerates ALS-like disease progression in a strain of mutant SOD1 transgenic ALS mice.
Guanabenz acetate exhibits anti-inflammatory activity by increasing in vitro IL-10 production by LPS-stimulated dendritic cells, prevents d-Galactosamine/LPS-induced liver damage and mortality in vivo.
