Catalog No.: PC-35559Not For Human Use, Lab Use Only.
JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR.
JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR.
JTT-551 exhibits clear selectivity against the other PTPs, increases the insulin-stimulated glucose uptake in L6 cells.
JTT-551 enhances the IR phosphorylation of liver and reduces the glucose level in ob/ob mice.
JTT-551 also shows a hypoglycaemic effect without an acceleration of body weight gain in db/db mice.
Physicochemical Properties
M.Wt
628.846
Formula
C34H43N3NaO3S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-((5-(tert-butyl)thiazol-2-yl)methyl)-N-((4-(4-((4-(heptan-4-yl)phenoxy)methyl)phenyl)thiazol-2-yl)methyl)glycine, sodium salt
References
1. Fukuda S, et al. Diabetes Obes Metab. 2010 Apr;12(4):299-306.
2. Ito M, et al. J Diabetes Res. 2014;2014:680348.
