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CPT157633

Chemical Structure : CPT157633

CAS No.: 888213-72-7

CPT157633 (CPT 157633;CPT-157633)

Catalog No.: PC-35178Not For Human Use, Lab Use Only.

CPT157633 is a novel potent, selective PTP1B inhibitor with Ki of 40 nM, shows markedly less activities against a panel of 6 PTPs and 2 dual-specificity phosphatases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CPT157633 is a novel potent, selective PTP1B inhibitor with Ki of 40 nM, shows markedly less activities against a panel of 6 PTPs and 2 dual-specificity phosphatases.
    CPT157633 prevents binge drinking-induced glucose intolerance in vivo.
    CPT157633 also ameliorates the X-linked neurological disorder Rett syndrome (RTT) phenotypes in male mouse models.

    Physicochemical Properties

    M.Wt 465.203
    Formula C12H16BrF2N2O6PS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Phosphonic acid, [[2-bromo-4-[(2S)-3-(methylamino)-2-[(methylsulfonyl)amino]-3-oxopropyl]phenyl]difluoromethyl]- (9CI)

    References

    1. Lindtner C, et al. Sci Transl Med. 2013 Jan 30;5(170):170ra14.

    2. Krishnan N, et al. J Clin Invest. 2015 Aug 3;125(8):3163-77.

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