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Cat. No. Product Name Information
PC-62362

ML119

HePTP inhibitor

ML119 (CID1357397, MLS-0090801) is a potent, selective hematopoietic protein tyrosine phosphatase (HePTP) inhibitor with IC50 of 0.21 uM, displays 25-fold selectivity over MKP-3.
PC-62320

Sephin1

PPP1R15A inhibitor

Sephin1 (Icerguastat, NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex.
PC-62319

Guanabenz

PP1-PPP1R15A inhibitor

Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-PPP1R15A holophosphatase complex.
PC-61822

SHP244

SHP2 inhibitor

SHP244 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 60 uM (SHP2 1-525), equipotent on the double mutant (SHP2T253M/Q257L IC50=68 uM), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM)..
PC-61676

AKB-9778

VE-PTP inhibitor

AKB-9778 (Razuprotafib) is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP, HPTPβ) with IC50 of 17 pM.
PC-61276

II-B08

SHP2 inhibitor

II-B08 is a potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs.
PC-61275

SHP2 inhibitor 11a-1

SHP2 inhibitor

SHP2 inhibitor 11a-1 is a potent, selective, cell-active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs.
PC-61273

SHP2 inhibitor 2

SHP2 inhibitor

SHP2 inhibitor 2 is a nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM.
PC-61272

GS-493

SHP2 inhibitor

GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay.
PC-61271

Fumosorinone

SHP2 inhibitor

Fumosorinone is a novel potent, selective protein tyrosine phosphatase SHP2 inhibitor with IC50 of 6.31 uM.
PC-61176

NSC 87877

SHP1/2 inhibitor

NSC 87877 is potent, selective protein tyrosine phosphatase SHP1 and SHP2 with IC50 of 318 and 355 nM, respectively, also inhibits dual-specificity phosphatase 26 (DUSP26).
PC-61175

RR601

DUSP5 inhibitor

RR601 is a potent, selective protein tyrosine phosphatase DUSP5, PTP1B and SHP-2 inhibitor with IC50 of 36 uM, 2.1 uM and 1.1 uM respectively, 8-fold selectivity for PTP1B versus DUSP5.

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