Catalog No.: PC-62320Not For Human Use, Lab Use Only.
Sephin 1 (Icerguastat, NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex.
Sephin 1 (Icerguastat, NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex.
Sephin 1 prolongs eIF2α phosphorylation after stress, attenuates the expression of stress genes such as CHOP, and protects cells from cytotoxic ER stress; lacks any measurable α2-adrenergic agonist activity in a cell-based assay, in contrast to Guanabenz.
Sephin 1 safely prevents the motor, morphological, and molecular defects in mice.
