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Chemical Structure : ML119
Catalog No.: PC-62362Not For Human Use, Lab Use Only.
ML119 (CID1357397, MLS-0090801) is a potent, selective hematopoietic protein tyrosine phosphatase (HePTP) inhibitor with IC50 of 0.21 uM, displays 25-fold selectivity over MKP-3.
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ML119 (CID1357397, MLS-0090801) is a potent, selective hematopoietic protein tyrosine phosphatase (HePTP) inhibitor with IC50 of 0.21 uM, displays 25-fold selectivity over MKP-3.
ML119 augments ERK1/2 and p38 activation in human T cells, prolongs activation of ERK1/2 and, especially, p38.
ML119 shows similar effects in leukocytes from mice intraperitoneally injected with the inhibitor at doses as low as 3 mg/kg.
| M.Wt | 468.281 | |
| Formula | C20H10BrN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sergienko E, et al. ACS Chem Biol. 2012 Feb 17;7(2):367-77.
2. Sergienko E, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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