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Guanabenz

Chemical Structure : Guanabenz

CAS No.: 5051-62-7

Guanabenz (WY 8678)

Catalog No.: PC-62319Not For Human Use, Lab Use Only.

Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-PPP1R15A holophosphatase complex.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-PPP1R15A holophosphatase complex.
Guanabenz also has antiparasitic activity against replicative stages of Toxoplasma.

Physicochemical Properties

M.Wt 231.08
Formula C8H8Cl2N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine

References

1. Das I, et al. Science. 2015 Apr 10;348(6231):239-42.

2. Crespillo-Casado A, et al. Elife. 2017 Apr 27;6. pii: e26109.

3. Benmerzouga I, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):6939-45.

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