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RR601

Chemical Structure : RR601

CAS No.: 1970119-63-1

RR601 (RR 601, RR-601)

Catalog No.: PC-61175Not For Human Use, Lab Use Only.

RR601 is a potent, selective protein tyrosine phosphatase DUSP5, PTP1B and SHP-2 inhibitor with IC50 of 36 uM, 2.1 and 1.1 uM respectively, 8-fold selectivity for PTP1B versus DUSP5.

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    Biological Activity

    RR601 is a potent, selective protein tyrosine phosphatase DUSP5, PTP1B and SHP-2 inhibitor with IC50 of 36 uM, 2.1 and 1.1 uM respectively, 8-fold selectivity for PTP1B versus DUSP5.
    RR601 has IC50 of 4.8 uM in pERK assays.

    Physicochemical Properties

    M.Wt 518.422
    Formula C20H12N2Na2O8S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    sodium (E)-8,8'-(diazene-1,2-diyl)bis(4-hydroxynaphthalene-2-sulfonate)

    References

    1. Bongard RD, et al. BMC Biochem. 2017 May 31;18(1):10.

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