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Chemical Structure : SHP2 inhibitor 2
Catalog No.: PC-61273Not For Human Use, Lab Use Only.
SHP2 inhibitor 2 is a nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM.
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SHP2 inhibitor 2 is a nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM.
SHP2 inhibitor 2 displays 5-fold selectivity over SHP1, and >10-fold secltivity over other PTPs.
SHP2 inhibitor 2 effectively reduces the EGF-induced ERK1/2 phosphorylation, increased the phosphorylation level of Y118 in paxillin, reduces H1975 cell proliferation in a dose-dependent manner.
| M.Wt | 579.365 | |
| Formula | C22H18IN3O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. He R, et al. ACS Med Chem Lett. 2015 Jun 8;6(7):782-6.
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