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SHP2 inhibitor 2

Chemical Structure : SHP2 inhibitor 2

CAS No.: 1799604-71-9

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SHP2 inhibitor 2

Catalog No.: PC-61273Not For Human Use, Lab Use Only.

SHP2 inhibitor 2 is a nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SHP2 inhibitor 2 is a nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM.
    SHP2 inhibitor 2 displays 5-fold selectivity over SHP1, and >10-fold secltivity over other PTPs.
    SHP2 inhibitor 2 effectively reduces the EGF-induced ERK1/2 phosphorylation, increased the phosphorylation level of Y118 in paxillin, reduces H1975 cell proliferation in a dose-dependent manner.

    Physicochemical Properties

    M.Wt 579.365
    Formula C22H18IN3O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((4-(2-((4-iodophenyl)amino)-2-oxoacetamido)phenyl)amino)-2-oxo-1-phenylethane-1-sulfonic acid

    References

    1. He R, et al. ACS Med Chem Lett. 2015 Jun 8;6(7):782-6.

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