| Cat. No. |
Product Name |
Information |
| PC-20365 |
HN252
PPM1B inhibitor
|
HN252 is a potent protein phosphatase 1B (PPM1B) inhibitor with Ki of 0.52 uM and IC50 of 0.76 uM, shows no inhibition against topoisomerases in vitro. |
| PC-20341 |
PHPS1 sodium
SHP2 inhibitor
|
PHPS1 sodium is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM. |
| PC-20340 |
PHPS1
SHP2 inhibitor
|
PHPS1 is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM. |
| PC-20339 |
PTPN2 inhibitor 9
PTPN2 inhibitor
|
PTPN2 inhibitor 9 (PTP9) is small molecule inhibitor of protein tyrosine phosphatase non-receptor type 2 (PTPN2), sensitizes tumor cells to IFNγ treatment in vitro and to anti-PD-1 therapy in vivo. |
| PC-20250 |
JAB-3068
SHP2 inhibitor
|
JAB-3068 (JAB3068) is a potent, selective and orally bioavailable allosteric inhibitor of SHP2 with IC50 of 25.8 nM. |
| PC-20047 |
GDC-1971
SHP2 inhibitor
|
Migoprotafib (GDC-1971, RLY-1971) is a potent, selective, allosteric and orally bioavailable inhibitor of the non-receptor protein tyrosine phosphatase SHP2 (PTPN11), potently inhibits both wild-type SHP2 (IC50 <1 nM) and E76K activating mutant (IC50 < 250nM) in biochemical assays. |
| PC-49364 |
SPAA-52
LMW-PTP inhibitor
|
SPAA-52 is a highly potent, selective inhibitor of the low-molecular-weight protein tyrosine phosphatase (LMW-PTP) with Ki of 1.2 nM, >8000-fold selectivity over other PTPs. |
| PC-49299 |
DS-1211
TNAP inhibitor
|
DS-1211 (DS1211) is a potent, selecitve inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with IC50 of 3.4 nM. |
| PC-49084 |
NSC49L
PP2A agonist
|
NSC49L (NSC30049) is a small molecule agonist (activator) of protein phosphatase 2A (PP2A), specifically stimulates PP2A-Cα activity with Kact of 14 nM, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. |
| PC-49039 |
PP2Cδ (WIP1) inhibitor C23
PP2Cδ inhibitor
|
PP2Cδ inhibitor C23 is a potent PP2Cδ (WIP1, PPM1D) inhibitor, not only directly inhibits PP2Cδ activity but also suppresses high glucose (HG)-induced PP2Cδ expression. |
| PC-49037 |
CCT007093
PP2Cδ/PPM1D/Wip1 inhibitor
|
CCT007093 is a small-molecule inhibitor of PP2Cδ (WIP1, PPM1D) with IC50 of 8.4 uM, selectively reduces viability of human tumour cell lines. |
| PC-38898 |
K306
SHIP1 agonist
|
K306 is a specific, small molecule agonist of SH2-containing 5' inositol phosphatase 1 (SHIP1) with EC50 of 119 nM, 10-fold higher selectivity over SHIP2. |
