| Cat. No. |
Product Name |
Information |
| PC-21977 |
LMPTP inhibitor 23 dihydrochloride
LMPTP inhibitor
|
LMPTP inhibitor 23 dihydrochloride is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM. |
| PC-21976 |
Raphin1 acetate
PPP1R15B inhibitor
|
Raphin1 acetate (PPP1R15B inhibitor Raphin1) is a potent, selective, BBB-penetrant, orally bioavailable inhibitor of regulatory subunit of protein phosphatase 1, PPP1R15B, binds to the R15B-PP1c holophosphatase with Kd of 33 nM, 30-fold selective in binding R15B-PP1c over R15A-PP1c and does not bind to PP1c. |
| PC-21911 |
G6P6373
CLas STP inhibitor
|
G6P6373 is a specific Candidatus Liberibacter spp dual-specificity phosphatase (CLas STP) with binding KD of 24 uM, confers plant tolerance to Candidatus Liberibacter spp. |
| PC-21645 |
Voclosporin
Calcineurin inhibitor
|
Voclosporin (ISATX247, ISA247) is a small molecule calcineurin (Protein phosphatase-2B, PP2B) inhibitor, more potency than cyclosporine in vitro, substantially inhibits lymphocyte proliferation, T-cell activation and cytokine production. |
| PC-21504 |
PRL inhibitor Cmpd-43
PRL inhibitor
|
PRL inhibitor Cmpd-43 is a specific small molecule inhibitor and detrimerizer of phosphatase of regenerating liver (PRL, PTP4A), significantly decreases PRL1 trimer formation inside the cell. |
| PC-21457 |
K161
SHIP1/2 inhibitor
|
K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively. |
| PC-21454 |
AS1938909
SHIP2 inhibitor
|
AS1938909 is a potent, selective and competitive SHIP2 inhibitor with Ki value of 0.44 uM (human SHIP2), shows significant selectivity over other related phosphatases. |
| PC-21366 |
ATUX-1215
PP2A activator
|
ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo. |
| PC-21359 |
ATUX-792
PP2A activator
|
ATUX-792 is a small molecule activator of protein phosphatase 2A (PP2A), decreases survival, proliferation, and motility of neuroblastoma in vitro and tumor growth in vivo. |
| PC-21296 |
PP5 inhibitor P053
PP5 inhibitor
|
PP5 inhibitor P053 (Compound P053) is a potent, selective and competitive inhibitor of serine/threonine protein phosphatase-5 (PP5) with Ki of 244 nM, specifically binds and inhibits PP5 activity. |
| PC-21074 |
PTPN22 inhibitor NC1
PTPN22 inhibitor
|
PTPN22 inhibitor NC1 is a specific, noncompetitive, allosteric PTPN22 (lymphoid-specific tyrosine phosphatase, LYP) inhibitor with Ki of 4.3 uM, effectively and specifically inhibits LYP-mediated TCR signaling in T cells. |
| PC-20969 |
Compound 182
PTP1B/PTPN2 inhibitor
|
Compound 182 is a highly potent and selective active site competitive inhibitor of PTP1B and PTPN2, inhibits the catalytic activities of PTP1B and PTPN2 with IC50 of 0.63 and 0.58 nM, respectively. |
