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Voclosporin

Chemical Structure : Voclosporin

CAS No.: 515814-01-4

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Voclosporin (ISATX247, ISA247)

Catalog No.: PC-21645Not For Human Use, Lab Use Only.

Voclosporin (ISATX247, ISA247) is a small molecule calcineurin inhibitor, more potency than cyclosporine in vitro, substantially inhibits lymphocyte proliferation, T-cell activation and cytokine production.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Voclosporin (ISATX247, ISA247) is a small molecule calcineurin inhibitor, more potency than cyclosporine in vitro, substantially inhibits lymphocyte proliferation, T-cell activation and cytokine production.

Physicochemical Properties

M.Wt 1214.62
Formula C63H111N11O12
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhepta-4,6-dienyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

References

1. Stalder M, et al. J Heart Lung Transplant. 2003 Dec;22(12):1343-52.

2. Aspeslet L, et al. Transplant Proc. 2001 Feb-Mar;33(1-2):1048-51.

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