Chemical Structure : SCP1 inhibitor GR-28
CAS No.:
SCP1 inhibitor GR-28
(GR-28)
Catalog No.: PC-22168Not For Human Use, Lab Use Only.
SCP1 inhibitor GR-28 is a covalent small molecule inhibitor of small C-terminal domain phosphatase 1 (SCP1) with kinact/KI 1383 min-1 M-1, causes degrades REST protein in REST-dependent glioblastoma cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SCP1 inhibitor GR-28 is a covalent small molecule inhibitor of small C-terminal domain phosphatase 1 (SCP1) with kinact/KI 1383 min-1 M-1, causes degrades REST protein in REST-dependent glioblastoma cells.
GR-28 inhibits SCP1 capacity to dephosphorylate REST leading to accumulation of phospho-REST and its subsequent proteasomal degradation in vitro.
SCP1 inhibitor GR-28 covalently targets SCP1 Cys 181, and SCP1 C181A mutant shows resistance to GR-28 inhibition.
SCP1 inhibitor GR-28 (4 uM) reduces the transcriptional activity of REST and GR-28 (10 uM) is cytotoxic against high-REST GBM cells.
SCP1 inhibitor GR-28 exhibits profound synergy with ACSL inhibitor Triacsin C in high-REST GBM cells.
Physicochemical Properties
|
M.Wt
|
476.55
|
|
Formula
|
C26H24N2O5S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(3-(2'-methoxy-[1,1'-biphenyl]-4-carboxamido)propyl)cinnamamide 1,1-dioxide
|
References
1. Svetlana B Panina, et al. BMC Biol. 2024 Apr 12;22(1):83.
Contact Us
sales@probechem.com
