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Chemical Structure : LMPTP inhibitor 6g
Catalog No.: PC-21979Not For Human Use, Lab Use Only.
LMPTP inhibitor 6g is a potent, selective, uncompetitive low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 83 nM, >1000-fold selective over other phosphatases.
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LMPTP inhibitor 6g is a potent, selective, uncompetitive low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 83 nM, >1000-fold selective over other phosphatases.
LMPTP inhibitor 6g (500 nM) substantially increased HepG2 AKT Thr308 phosphorylation after insulin stimulation. (30 mg/kg/day, oral) significantly improved glucose tolerance and decreased fasting insulin levels of diabetic DIO mice.
LMPTP inhibitor 6g also resulted in increased insulin-stimulated phosphorylation of the IR activation motif and increased phosphorylation of AKT Thr308 in the livers of DIO mice.
| M.Wt | 295.13 | |
| Formula | C11H8Cl2N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stanford SM, et al. J Med Chem. 2021 May 13;64(9):5645-5653.
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