Chemical Structure : LMPTP inhibitor 6g
CAS No.:
2361514-45-4
LMPTP inhibitor 6g
Catalog No.: PC-21979Not For Human Use, Lab Use Only.
LMPTP inhibitor 6g is a potent, selective, uncompetitive low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 83 nM, >1000-fold selective over other phosphatases.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LMPTP inhibitor 6g is a potent, selective, uncompetitive low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 83 nM, >1000-fold selective over other phosphatases.
LMPTP inhibitor 6g (500 nM) substantially increased HepG2 AKT Thr308 phosphorylation after insulin stimulation. (30 mg/kg/day, oral) significantly improved glucose tolerance and decreased fasting insulin levels of diabetic DIO mice.
LMPTP inhibitor 6g also resulted in increased insulin-stimulated phosphorylation of the IR activation motif and increased phosphorylation of AKT Thr308 in the livers of DIO mice.
Physicochemical Properties
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M.Wt
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295.13
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Formula
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C11H8Cl2N6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-((3,5-dichloropyridin-4-yl)methyl)-3H-purin-6-amine
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References
1. Stanford SM, et al. J Med Chem. 2021 May 13;64(9):5645-5653.
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