| Cat. No. |
Product Name |
Information |
| PC-23571 |
Ethoxysanguinarine
CIP2A inhibitor
|
Ethoxysanguinarine (ESG) is an effective small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and its downstream signaling molecules, c-Myc and pAkt, and induces protein phosphatase 2A (PP2A) activity. |
| PC-23570 |
CIP2A inhibitor TD52
CIP2A inhibitor
|
TD52 is a small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and p-Akt, reactivates protein phosphatase 2A. |
| PC-23264 |
SP3-12
SHIP-1 inhibitor
|
SP3-12 is a novel selective small molecule inhibitor of Src Homology 2-containing Inositol 5'-Phosphatase-1 (SHIP-1, encoded by INPP5D) with IC50 of 6.1 uM and Ki of 3.2 µM, 7-fold selectivity over SHIP-2. |
| PC-23195 |
SPI-112
SHP2 inhibitor
|
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50 of 1 uM. |
| PC-23188 |
ENT-03
PTP1B inhibitor
|
ENT-03 is a centrally acting spermine bile acid, potently inhibits PTP1B with IC50 of 10 nM, induces weight loss in obese and lean rodents. |
| PC-23059 |
ABBV-CLS-579
PTP1B/PTPN2 inhibitor
|
Tegeprotafib (ABBV-CLS-579) is a potent, selective orally active PTP1B/PTPN2 inhibitor. |
| PC-23044 |
TK-642
SHP2 inhibitor
|
TK-642 is a highly potent, selective, orally bioavailable, allosteric SHP2 inhibitor with IC50 of 2.7 nM (SHP2WT) and Ki of 1.53 nM. |
| PC-22998 |
BN82002 hydrochloride
Cdc25 phosphatase inhibitor
|
BN82002 hydrochloride is a potent Cdc25 dual specificity phosphatase inhibitor with IC50 of 2-6 uM for Cdc25A/B/C. |
| PC-22917 |
DDO-3733
PP5 activator
|
DDO-3733 is a specific, small molecule, allosteric activator of serine/threonine protein phosphatase 5 (PP5) with potency of 2.9-fold PP5 activation at 50 uM, inhibits HSP90 inhibitor-induced heat shock protein expression both in cells and in vivo. |
| PC-22889 |
JAB-3312
SHP2 inhibitor
|
JAB-3312 is a potent, selective and allosteric SHP2 inhibitor with binding Kd of 0.37 nM and enzymatic IC50 of 1.9 nM. |
| PC-22858 |
PTP4A3 inhibitor BR-1
PTP4A3 inhibitor
|
PTP4A3 inhibitor BR-1 is a specfiic inhibitor of PTP4A3 (PRL-3, phosphatase of regenerating liver-3) with IC50 of 1.1 uM, selective over other 10 phosphatases, inhibits the migration and invasion of metastatic cancer cells. |
| PC-22857 |
CG-707
PTP4A3 inhibitor
|
CG-707 is a specfiic inhibitor of PTP4A3 (PRL-3, phosphatase of regenerating liver-3) with IC50 of 0.8 uM, selective over other 10 phosphatases, inhibits the migration and invasion of metastatic cancer cells. |
