| Cat. No. |
Product Name |
Information |
| PC-23059 |
ABBV-CLS-579
PTP1B/PTPN2 inhibitor
|
Tegeprotafib (ABBV-CLS-579) is a potent, selective orally active PTP1B/PTPN2 inhibitor. |
| PC-23044 |
TK-642
SHP2 inhibitor
|
TK-642 is a highly potent, selective, orally bioavailable, allosteric SHP2 inhibitor with IC50 of 2.7 nM (SHP2WT) and Ki of 1.53 nM. |
| PC-22998 |
BN82002 hydrochloride
Cdc25 phosphatase inhibitor
|
BN82002 hydrochloride is a potent Cdc25 dual specificity phosphatase inhibitor with IC50 of 2-6 uM for Cdc25A/B/C. |
| PC-22917 |
DDO-3733
PP5 activator
|
DDO-3733 is a specific, small molecule, allosteric activator of serine/threonine protein phosphatase 5 (PP5) with potency of 2.9-fold PP5 activation at 50 uM, inhibits HSP90 inhibitor-induced heat shock protein expression both in cells and in vivo. |
| PC-22889 |
JAB-3312
SHP2 inhibitor
|
JAB-3312 is a potent, selective and allosteric SHP2 inhibitor with binding Kd of 0.37 nM and enzymatic IC50 of 1.9 nM. |
| PC-22858 |
PTP4A3 inhibitor BR-1
PTP4A3 inhibitor
|
PTP4A3 inhibitor BR-1 is a specfiic inhibitor of PTP4A3 (PRL-3, phosphatase of regenerating liver-3) with IC50 of 1.1 uM, selective over other 10 phosphatases, inhibits the migration and invasion of metastatic cancer cells. |
| PC-22857 |
CG-707
PTP4A3 inhibitor
|
CG-707 is a specfiic inhibitor of PTP4A3 (PRL-3, phosphatase of regenerating liver-3) with IC50 of 0.8 uM, selective over other 10 phosphatases, inhibits the migration and invasion of metastatic cancer cells. |
| PC-22856 |
Thienopyridone
PRL/PTP4A inhibitor
|
Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatases inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1 (PTP4A1), PRL-2 (PTP4A2), and PRL-3 (PTP4A3), respectively. |
| PC-22839 |
Cyclosporin A
PP2B inhibitor
|
Cyclosporin A (CsA, Cyclosporine A) is a immunosuppressant agent and highly specific inhibitor of the Ca2+/calmodulin-dependent protein phosphatase PP2B with IC50 of 65 nM in rat pancreatic acinar cells. |
| PC-22546 |
SMIP-031
PPM1A inhibitor
|
SMIP-031 is a potent small molecule inhibitor of metal-dependent phosphatase PPM1A with IC50 of 180 nM, efficiently activates autophagy and reduces the mycobacterium tuberculosis (Mtb) infection. |
| PC-22375 |
CDC14 phosphatase inhibitor 15
CDC14 inhibitor
|
CDC14 phosphatase inhibitor 15 is a first-in-class, potent, selective, and bioavailable inhibitor of CDC14 phosphatase with IC50 of 93 nM and 220 nM for human CDC14A and CDC14B, respectively, >50-fold selective over other PTPs. |
| PC-22168 |
SCP1 inhibitor GR-28
SCP1/REST inhibitor
|
SCP1 inhibitor GR-28 is a covalent small molecule inhibitor of small C-terminal domain phosphatase 1 (SCP1) with kinact/KI 1383 min-1 M-1, causes degrades REST protein in REST-dependent glioblastoma cells. |
