| Cat. No. |
Product Name |
Information |
| PC-42696 |
PTP1B-IN-1
PTP1B inhibitor
|
PTP1B-IN-1 is a 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for design of protein tyrosine phosphatase-1B (PTP1B) inhibitor, shows weak inhibition for PTP1B with IC50 of 1.6 mM. |
| PC-24364 |
Laforin inhibitor 9c
Laforin inhibitor
|
Laforin inhibitor 9c is a highly potent, selective inhibitor of glycogen phosphatase laforin with IC50 of 4.0 nM and Ki value of 1.9 nM, >8000-fold selective over other 15 PTPs. |
| PC-23908 |
PTPN22 inhibitor IC-11
PTPN22 inhibitor
|
I-C11 is a selective, reversible inhibitor of protein tyrosine phosphatase non-receptor type 22 (PTPN22, LYP) with IC50 of 4.6 uM. |
| PC-23638 |
PTPN22 inhibitor 8b
PTPN22 inhibitor
|
PTPN22 inhibitor 8b is a potent, selective inhibitor of lymphoid-specific tyrosine phosphatase (LYP, PTPN22) with Ki/IC50 of 110/260 nM, > 9-fold selectivity over a large panel of PTPs. |
| PC-23637 |
PTPN22 inhibitor 8b-19
PTPN22 inhibitor
|
PTPN22 inhibitor 8b-19 is a potent, selective inhibitor of protein tyrosine phosphatase non-receptor type 22 (PTPN22) with IC50 of 0.25 uM, 15.2-fold and 19.2-fold selectivity against SHP2 and PTP1B, respectively. |
| PC-23571 |
Ethoxysanguinarine
CIP2A inhibitor
|
Ethoxysanguinarine (ESG) is an effective small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and its downstream signaling molecules, c-Myc and pAkt, and induces protein phosphatase 2A (PP2A) activity. |
| PC-23570 |
CIP2A inhibitor TD52
CIP2A inhibitor
|
TD52 is a small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and p-Akt, reactivates protein phosphatase 2A. |
| PC-23264 |
SP3-12
SHIP-1 inhibitor
|
SP3-12 is a novel selective small molecule inhibitor of Src Homology 2-containing Inositol 5'-Phosphatase-1 (SHIP-1, encoded by INPP5D) with IC50 of 6.1 uM and Ki of 3.2 µM, 7-fold selectivity over SHIP-2. |
| PC-23195 |
SPI-112
SHP2 inhibitor
|
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50 of 1 uM. |
| PC-23188 |
ENT-03
PTP1B inhibitor
|
ENT-03 is a centrally acting spermine bile acid, potently inhibits PTP1B with IC50 of 10 nM, induces weight loss in obese and lean rodents. |
| PC-23044 |
TK-642
SHP2 inhibitor
|
TK-642 is a highly potent, selective, orally bioavailable, allosteric SHP2 inhibitor with IC50 of 2.7 nM (SHP2WT) and Ki of 1.53 nM. |
| PC-22998 |
BN82002 hydrochloride
Cdc25 phosphatase inhibitor
|
BN82002 hydrochloride is a potent Cdc25 dual specificity phosphatase inhibitor with IC50 of 2-6 uM for Cdc25A/B/C. |
