LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor.
LB100 exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM.
LB100 synergistically enhances the activity of doxorubicin and induces expression of HIF-1α and VEGF.
LB100 significantly enhances tumor growth inhibition by cisplatin in vivo.
