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Chemical Structure : TPI-1
CAS No.: 79756-69-7
Catalog No.: PC-42166Not For Human Use, Lab Use Only.
TPI-1 is a potent and selective, orally-active protein tyrosine phosphatases SHP-1 inhibitor with IC50 of 40 nM (0.01 ug/ml).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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TPI-1 is a potent and selective, orally-active protein tyrosine phosphatases SHP-1 inhibitor with IC50 of 40 nM (0.01 ug/ml).
TPI-1 has limited impact on recombinant MKP1 (IC50> 1 ug/ml) or SHP-2 (IC50 ~ 0.1 ug/ml).
TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells at low nM, does not affect pLck-pY505 or pERK1/2.
TPI-1 induces mouse splenic-IFN-gamma(+) cells, also induces IFN-γ(+) cells in human peripheral blood in vitro.
TPI-1 inhibits the growth of B16 melanoma tumors in mice in a T cell-dependent manner.
| M.Wt | 253.0808 | |
| Formula | C12H6Cl2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)- |
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1. Kundu S, et al. J Immunol. 2010 Jun 1;184(11):6529-36.
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