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Laforin inhibitor 9c

Chemical Structure : Laforin inhibitor 9c

CAS No.:

Laforin inhibitor 9c

Catalog No.: PC-24364Not For Human Use, Lab Use Only.

Laforin inhibitor 9c is a highly potent, selective inhibitor of glycogen phosphatase laforin with IC50 of 4.0 nM and Ki value of 1.9 nM, >8000-fold selective over other 15 PTPs.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Laforin inhibitor 9c is a highly potent, selective inhibitor of glycogen phosphatase laforin with IC50 of 4.0 nM and Ki value of 1.9 nM, >8000-fold selective over other 15 PTPs.
Laforin inhibitor 9c efficiently blocks laforin-mediated glucan dephosphorylation inside the cell and possess favorable pharmacokinetic properties in mice. 

Physicochemical Properties

M.Wt 586.06
Formula C28H28ClN3O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-((2-(2-((3-Chloro-4-phenoxyphenyl)amino)-2-oxoacetamido)cyclohexyl)amino)-2-oxo-1-phenylethanesulfonic Acid

References

1. Lin J, et al. J Med Chem. 2025 Apr 16. doi: 10.1021/acs.jmedchem.4c02580.

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