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Chemical Structure : NQ301
CAS No.: 130089-98-4
Catalog No.: PC-42304Not For Human Use, Lab Use Only.
NQ301 (CD45 inhibitor 211, Compound 211) is a potent antithrombotic agent that inhibits thromboxane A2 receptor and synthase activity, also is a potent, selective inhibitor of CD45 tyrosine phosphatase with IC50 of 200 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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NQ301 (CD45 inhibitor 211, Compound 211) is a potent antithrombotic agent that inhibits thromboxane A2 receptor and synthase activity, also is a potent, selective inhibitor of CD45 tyrosine phosphatase with IC50 of 200 nM.
NQ301 displays >100-fold selectivity over other related PTPs (LAR, PTP1B, PTP-σ, SHP-1 and MKPX).
NQ301 inhibits platelet aggregation induced by collagen, arachidonic acid and U46619 with IC50 of 0.6, 0.78 and 0.58 uM, respectivey.
NQ301 also significantly inhibits FITC-conjugated fibrinogen binding to human platelet surface GPIIb/IIIa complex.
NQ301 significantly inhibits the increase of cytosolic Ca2+ concentration, ATP secretion and platelet cAMP levels in the activated platelets.
| M.Wt | 325.74578 | |
| Formula | C18H12ClNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
1,4-Naphthalenedione, 2-[(4-acetylphenyl)amino]-3-chloro- |
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1. Kang WS, et al. Biol Pharm Bull. 1999 Dec;22(12):1284-7.
2. Zhang YH, et al. Biol Pharm Bull. 2001 Jun;24(6):618-22.
3. Perron MD, et al. Mol Pharmacol. 2014 Apr;85(4):553-63.
4. Perron M, et al. Mol Pharmacol. 2018 Mar 19. pii: mol.117.110908.
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