PTPN22 inhibitor IC-11 | PTPN22 inhibitor

Chemical Structure : PTPN22 inhibitor IC-11

PTPN22 inhibitor IC-11 (I-C11)

Catalog No.: PC-23908Not For Human Use, Lab Use Only.

I-C11 is a selective, reversible inhibitor of protein tyrosine phosphatase non-receptor type 22 (PTPN22, LYP) with IC50 of 4.6 uM.

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Biological Activity

I-C11 is a selective, reversible inhibitor of protein tyrosine phosphatase non-receptor type 22 (PTPN22, LYP) with IC50 of 4.6 uM.
I-C11 displays >7-fold selectivity against a panel of PTPs including cytosolic PTPs, PTP1B, SHP2, HePTP, PTP-Meg2, and FAP1, the receptor-like PTPs, CD45, LAR, and PTPα, and the dual specificity phosphatase VHR.

Physicochemical Properties

M.Wt	532.56
Formula	C31H24N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)-2-phenylbenzofuran-5-carboxylic acid

References

1. Xiao Yu, et al. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19767-72.

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PTPN22 inhibitor IC-11 (I-C11)

Biological Activity

Physicochemical Properties

References

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