| Cat. No. |
Product Name |
Information |
| PC-42128 |
SHP-099
SHP2 inhibitor
|
SHP-099 (SHP099) is a potent, selective, allosteric and orally bioavailable protein tyrosine phosphatase SHP2 inhibitor with IC50 of 71 nM. |
| PC-47481 |
Microcystin-LR
PP2A inhibitor
|
Microcystin-LR (MC-LR) is a potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM. |
| PC-45526 |
CPDA
SHIP2 inhibitor
|
CPDA is a potent SHIP2 inhibitor that enhances in vitro insulin signaling through the Akt pathway more efficiently than AS1949490, and ameliorates abnormal glucose metabolism in diabetic (db/db) mice. |
| PC-45470 |
LB-100
PP2A inhibitor
|
LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor. |
| PC-42304 |
NQ301
CD45 inhibitor
|
NQ301 (CD45 inhibitor 211, Compound 211) is a potent antithrombotic agent that inhibits thromboxane A2 receptor and synthase activity, also is a potent, selective inhibitor of CD45 tyrosine phosphatase with IC50 of 200 nM. |
| PC-42166 |
TPI-1
SHP1 inhibitor
|
TPI-1 is a potent and selective, orally-active protein tyrosine phosphatases SHP-1 inhibitor with IC50 of 40 nM (0.01 ug/ml). |
| PC-42207 |
Stibogluconate sodium
PTPs inhibitor
|
Stibogluconate sodium (Sodium stibogluconate) is a multiple antimony compound that has leishmanicidal and potential antineoplastic activities, inhibits protein tyrosine phosphorylase SHP-1 (99% inhibtion at 10 ug/mL), SHP-2 and PTP1B, shows anticancer activity in synergy with IFNs. |
| PC-45510 |
LTV-1
Lymphoid tyrosine phosphatase inhibitor
|
LTV-1 is a highly potent, cell-permeable and reversible LYP (lymphoid tyrosine phosphatase) inhibitor with IC50 of 508 nM. |
| PC-42696 |
PTP1B-IN-1
PTP1B inhibitor
|
PTP1B-IN-1 is a 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for design of protein tyrosine phosphatase-1B (PTP1B) inhibitor, shows weak inhibition for PTP1B with IC50 of 1.6 mM. |
| PC-23264 |
SP3-12
SHIP-1 inhibitor
|
SP3-12 is a novel selective small molecule inhibitor of Src Homology 2-containing Inositol 5'-Phosphatase-1 (SHIP-1, encoded by INPP5D) with IC50 of 6.1 uM and Ki of 3.2 µM, 7-fold selectivity over SHIP-2. |
| PC-23195 |
SPI-112
SHP2 inhibitor
|
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50 of 1 uM. |
| PC-23188 |
ENT-03
PTP1B inhibitor
|
ENT-03 is a centrally acting spermine bile acid, potently inhibits PTP1B with IC50 of 10 nM, induces weight loss in obese and lean rodents. |
