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GS-493

Chemical Structure : GS-493

CAS No.: 1710337-31-7

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GS-493 (GS 493;GS493)

Catalog No.: PC-61272Not For Human Use, Lab Use Only.

GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GS-493 (GS493) is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay.
    GS-493 displays 29- and 45-fold selectivity against related SHP1 and PTP1B.
    GS-493 blocks HGF-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells, and inhibits cell colony formation in the NSCLC cell line LXFA 526L in soft agar.
    GS-493 inhibits tumor growth in murine xenograft model.

    Physicochemical Properties

    M.Wt 510.437
    Formula C21H14N6O8S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-{(2Z)-2-[1,3-bis(4-nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden]hydrazino}benzenesulfonic acid

    References

    1. Grosskopf S, et al. ChemMedChem. 2015 May;10(5):815-26.

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