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Chemical Structure : BCI-215
CAS No.: 1245792-67-9
Catalog No.: PC-60691Not For Human Use, Lab Use Only.
BCI-215 (BCI215) is a potent, tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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BCI-215 (BCI215) is a potent, tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor.
BCI-215 restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells.
BCI-215 inhibits cell motility, causes apoptosis but not primary necrosis, and sensitizes cells to lymphokine-activated killer cell activity in MDA-MB-231 human breast cancer cells.
BCI-215 induces rapid and sustained phosphorylation of ERK, p38 and JNK, also hyperactivates MKK4/SEK1.
BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling.
| M.Wt | 396.328 | |
| Formula | C22H22BrNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-2-benzylidene-5-bromo-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one |
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1. Kaltenmeier CT, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):39-50.
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