Chemical Structure : SHP2 inhibitor 11a-1
CAS No.:
1620746-09-9
SHP2 inhibitor 11a-1
Catalog No.: PC-61275Not For Human Use, Lab Use Only.
SHP2 inhibitor 11a-1 is a potent, selective, cell-active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SHP2 inhibitor 11a-1 is a potent, selective, cell-active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs.
SHP2 inhibitor 11a-1 specifically attenuates the SHP2-dependent signaling in cells.
SHP2 inhibitor 11a-1 blocks growth factor mediated Erk1/2 and Akt activation and exhibits excellent antiproliferative activity in lung cancer and breast cancer as well as leukemia cell lines.
SHP2 inhibitor 11a-1 ameliorates the pathogenesis of systemic lupus erythematosus in mice.
Physicochemical Properties
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M.Wt
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637.448
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Formula
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C28H20IN3O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-Hydroxy-3-iodo-1-methyl-2-(3-(2-oxo-2-((4-(thiophen-3-yl)phenyl)amino)acetamido)phenyl)-1H-indole-5-carboxylic Acid
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References
1. Zeng LF, et al. J Med Chem. 2014 Aug 14;57(15):6594-609.
2. Wang J, et al. J Clin Invest. 2016 Jun 1;126(6):2077-92.
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