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Chemical Structure : SHP2 inhibitor 11a-1
Catalog No.: PC-61275Not For Human Use, Lab Use Only.
SHP2 inhibitor 11a-1 is a potent, selective, cell-active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs.
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SHP2 inhibitor 11a-1 is a potent, selective, cell-active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs.
SHP2 inhibitor 11a-1 specifically attenuates the SHP2-dependent signaling in cells.
SHP2 inhibitor 11a-1 blocks growth factor mediated Erk1/2 and Akt activation and exhibits excellent antiproliferative activity in lung cancer and breast cancer as well as leukemia cell lines.
SHP2 inhibitor 11a-1 ameliorates the pathogenesis of systemic lupus erythematosus in mice.
| M.Wt | 637.448 | |
| Formula | C28H20IN3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zeng LF, et al. J Med Chem. 2014 Aug 14;57(15):6594-609.
2. Wang J, et al. J Clin Invest. 2016 Jun 1;126(6):2077-92.
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