| Cat. No. |
Product Name |
Information |
| PC-72996 |
NSC45586 free base
PHLPP2 inhibitor
|
NSC45586 free base (NCS 45586, NCI45586) is a potent, specific PHLPP2 inhibitor with IC50 of 4 uM, targets the PHLPP2 PP2C domain, suppresses MYC and triggers cell death. |
| PC-72973 |
DIPQUO
Alkaline phosphatase activator
|
DIPQUO is a small molecule activator of the bone marker alkaline phosphatase (ALP) expression with EC50 of 6.27 uM, p38-β mediate DIQPUO-driven osteoblast differentiation effect. |
| PC-72803 |
MPK5 inhibitor 1
MKP5 inhibitor
|
MPK5 inhibitor 1 (MPK5-IN-1, MPK5 inhibitor compound 1) is a potent, selective allosteric inhibitor of MAPK phosphatase MKP5 with Kd/IC50 of 1.0/3.9 uM. |
| PC-72611 |
PF-07284892
SHP2 inhibitor
|
PF-07284892 (ARRY-558) is a potent, selective allosteric SHP2 inhibitor with IC50 of 21 nM, has 1,000-fold selectivity for SHP2 over 21 other phosphatases, including the closely related SHP1. |
| PC-72527 |
SMIP-30
PPM1A inhibitor
|
SMIP-30 is a potent and selective inhibitor of PPM1A with IC50 of 1 uM, selectively inhibits the phosphatase activity of PPM1A. |
| PC-72526 |
SCP1 inhibitor T-62
SCP1 inhibitor
|
SCP1 inhibitor T-62 (T-62) is a specific, small molecule covalent inhibitor of small CTD phosphatase 1 (SCP1), reduces transcription factor REST protein level HEK293 cells. |
| PC-72524 |
SCP1 inhibitor T-65
SCP1 inhibitor
|
SCP1 inhibitor T-65 (T-65) is a specific, small molecule covalent inhibitor of small CTD phosphatase 1 (SCP1), reduces transcription factor REST protein level HEK293 cells with EC50 of 1.5 uM. |
| PC-72326 |
TK-453
SHP2 inhibitor
|
TK-453 (TK453) is a potent, selective SHP2 allosteric inhibitor with IC50 of 18.76 and 179 nM for SHP2-WT and SHP2-E76K, respectively. |
| PC-72034 |
PTPN22 inhibitor L-1
PTPN22 inhibitor
|
PTPN22 inhibitor L-1 is a selective, competitive small molecule inhibitor of PTPN22 with IC50 of 1.4 uM, Ki of 0.5 uM, 7- to 10-fold selectivity for PTPN22 over 16 similar PTPs. |
| PC-72033 |
CNBDA
SHP2 inhibitor
|
CNBDA is a novel selective Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitor with IC50 of 5 uM, 25-fold selectivity over SHP1. |
| PC-38186 |
IACS-15414
SHP2 inhibitor
|
IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM. |
| PC-38184 |
SBI-4668
SHP2 inhibitor
|
SBI-4668 (SBI-668) is a novel furanylbenzamide molecule inhibitor of both WT and oncogenic SHP2 with IC50 of 0.73/1.8 uM for Wt SHP2/SHP2-E76K, 13-fold selective over PTP1B and 73-fold selective over STEP. |
