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SHP2 inhibitor 8

Chemical Structure : SHP2 inhibitor 8

CAS No.: 2055757-51-0

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SHP2 inhibitor 8

Catalog No.: PC-36039Not For Human Use, Lab Use Only.

SHP2 inhibitor 8 is a potent, selective inhibitor of SHP2 with IC50 of 5 nM, inhibits p-ERK in KYSE520 cells with IC50 of 5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SHP2 inhibitor 8 is a potent, selective inhibitor of SHP2 with IC50 of 5 nM, inhibits p-ERK in KYSE520 cells with IC50 of 5 nM.
    SHP2 inhibitor 8 demonstrates antiproliferation activity in the EGFR amplified human esophageal squamous cell carcinoma cell line KYSE520 (IC50=69 nM).
    SHP2 inhibitor 8 also inhibits Detroit-562 pharyngeal carcinoma cell line in vitro with IC50 of 1.38 uM.
    SHP2 inhibitor 8 inhibits p-ERK and DUSP6, shows efficacy in KYSE520 tumor implanted immunocompromised mice.

    Physicochemical Properties

    M.Wt 470.41
    Formula C20H25Cl2N5O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-((2,3-dichlorophenyl)thio)-3-methylpyrimidin-4(3H)-one

    References

    1. Sarver P, et al. J Med Chem. 2019 Jan 28. doi: 10.1021/acs.jmedchem.8b01726.

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