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Chemical Structure : SHP2 inhibitor 8
Catalog No.: PC-36039Not For Human Use, Lab Use Only.
SHP2 inhibitor 8 is a potent, selective inhibitor of SHP2 with IC50 of 5 nM, inhibits p-ERK in KYSE520 cells with IC50 of 5 nM.
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SHP2 inhibitor 8 is a potent, selective inhibitor of SHP2 with IC50 of 5 nM, inhibits p-ERK in KYSE520 cells with IC50 of 5 nM.
SHP2 inhibitor 8 demonstrates antiproliferation activity in the EGFR amplified human esophageal squamous cell carcinoma cell line KYSE520 (IC50=69 nM).
SHP2 inhibitor 8 also inhibits Detroit-562 pharyngeal carcinoma cell line in vitro with IC50 of 1.38 uM.
SHP2 inhibitor 8 inhibits p-ERK and DUSP6, shows efficacy in KYSE520 tumor implanted immunocompromised mice.
| M.Wt | 470.41 | |
| Formula | C20H25Cl2N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarver P, et al. J Med Chem. 2019 Jan 28. doi: 10.1021/acs.jmedchem.8b01726.
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