Catalog No.: PC-36050Not For Human Use, Lab Use Only.
SHP389 (SHP-389, SHP 389) is a novel potent, selective, allosteric SHP2 inhibitor with IC50 of 36 nM, shows with impressive hERG selectivity (IC50>30 uM).
SHP389 (SHP-389, SHP 389) is a novel potent, selective, allosteric SHP2 inhibitor with IC50 of 36 nM, shows with impressive hERG selectivity (IC50>30 uM).
SHP389 inhibits p-ERK in KYSE-520 cells with IC50 of 36 nM, and shows antiproliferation effect with IC50 of 0.36 uM.
SHP389 demonstrated a moderate-high clearance ~83% hepatic extraction) which was under predicted in vitro by rat liver microsomes (Cl= 26.1 uL/min/mg, T1/2 = 53.2 min) assuming a hepatic blood flow of 55 mL/min/kg.
SHP389 also showed low oral bioavailability (~2 %F).
