| Cat. No. |
Product Name |
Information |
| PC-62543 |
DPM-1001
PTP1B inhibitor
|
DPM-1001 is a potent, selective, orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B with IC50 of 100 nM, also chelates copper, which enhanced its potency as a PTP1B inhibitor. |
| PC-62443 |
Bisperoxovanadium
PTPs inhibitor
|
Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=343 nM), and PTP-1β (IC50=920 nM). |
| PC-62376 |
YU142670
INPP5B inhibitor
|
YU142670 is a highly specific, soluble OCRL/INPP5B inhibitor that directly interacts with the catalytic domain of INPP5B. |
| PC-62362 |
ML119
HePTP inhibitor
|
ML119 (CID1357397, MLS-0090801) is a potent, selective hematopoietic protein tyrosine phosphatase (HePTP) inhibitor with IC50 of 0.21 uM, displays 25-fold selectivity over MKP-3. |
| PC-62320 |
Sephin 1
PPP1R15A inhibitor
|
Sephin 1 (Icerguastat, NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex. |
| PC-62319 |
Guanabenz
PP1-PPP1R15A inhibitor
|
Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-PPP1R15A holophosphatase complex. |
| PC-61822 |
SHP244
SHP2 inhibitor
|
SHP244 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 60 uM (SHP2 1-525), equipotent on the double mutant (SHP2T253M/Q257L IC50=68 uM), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).. |
| PC-61676 |
AKB-9778
VE-PTP inhibitor
|
AKB-9778 (Razuprotafib) is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP, HPTPβ) with IC50 of 17 pM. |
| PC-61276 |
II-B08
SHP2 inhibitor
|
II-B08 is a potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs. |
| PC-61275 |
SHP2 inhibitor 11a-1
SHP2 inhibitor
|
SHP2 inhibitor 11a-1 is a potent, selective, cell-active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs. |
| PC-61273 |
SHP2 inhibitor 2
SHP2 inhibitor
|
SHP2 inhibitor 2 is a nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM. |
| PC-61272 |
GS-493
SHP2 inhibitor
|
GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay. |
